陳俊杰

陳俊杰

職稱：專任助理教授【基礎醫學組】

姓名：陳俊杰  

電話：037-728855

分機：

電子信箱：

p02786@gm.jente.edu.tw

學歷:

國立台灣大學醫學院藥理學研究所 博士 

國立台灣大學醫學院藥理學研究所 碩士

大仁藥學專科學校 藥學科 副學士

實務及教學經歷：

仁德醫護管理專科學校 助理教授
台灣大學醫學院藥理學研究所 博士後研究員
美國藥物食品監管局(FDA) 研究員
義大醫院醫學研究部腫瘤生物研究室 主持人
義守大學醫學院國際醫學系專班 兼任教師
輔英科技大學 醫學檢驗學系碩士班 兼任教師
中國深圳科興製藥有限公司新藥中心 高級總監
中國深圳碳雲智能有限公司 首席科學官

專業證照：

藥師執照

校內外學術服務:

  1. 護理科導師

研究成果:

學術論文：

  1. 碩士論文：進一步探討細胞素在人類肺泡上皮細胞引環氧化酶及黏著分子表現之訊息傳遞途徑
  2. 博士論文：蛋白解體抑制劑引發基因轉錄與細胞凋亡之探討

期刊論文：

  1. Jun-Jie, Chen, William P. Bozza, Xu Di, Yaqin Zhang, William Hallett and Baolin Zhang. H-Ras regulation of TRAIL death receptor mediated apoptosis. Oncotarget 2014 Jul. 5(13):5125-5137.
  2. Jun-Jie, Chen, Constanotinos Mikelis, Yaqin Zhang, Silvio J. Gutkind, Zhang baolin.TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. Oncotarget 2013 Feb. 4(2):206-217.
  3. Jun-Jie, Chen, Jennifer H, Shen, Yaqin, Zhang, Leslie, Rivera, Xu Di, Baolin, Zhang. Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells. Oncotarget 2012 Aug. ;3(8):833-42.
  4. Jun-Jie Chen, Steen Knudsen, Wiktor Mazin, jesper Dahlgaard, and Baolin Zhang. A 71-gene signature of TRAIL sensitivity in cancer cells. Mol Cancer Ther. 2012 Jan. 11(1); 34-44
  5. Zhigang Kang, Jun-Jie Chen, Lee J. Helman, Baolin Zhang, Liang Cao. Drozitumab, a human antibody to death receptor 5 has potent anti-tumor activity against rhabdo – myosarcoma with expression of caspase-8 predictive of response. Clinical Cancer Research 2011 May 15;17(10):3181-3192
  6. Yoshida T, Zhang Y, Rivera Rosado LA, Chen J, Khan T, Moon SY, Zhang B. Blockade of Rac1 activity induces G(1) cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein. Mol Cancer Ther. 2010 Jun;9(6):1657-68.
  7. Jun-Jie Chen, Chia-Wei Chou, Yu-Fan Chang and Ching-Chow Chen. (2008) Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-κB and reactive oxygen species-mediated p53 activation. J Immunol. 180(12):8030-9.
  8. Jun-Jie Chen, Wei-Chien Huang, and Ching-Chow Chen. (2005) Transcriptional regulation of cylcooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer binding protein delta and CREB-binding protein. Mol. Biol. Cell 16: 5579-5591.
  9. Wei-Chien Huang, Jun-Jie Chen, Hiroyasu Inoue and Ching-Chow Chen. (2003) Tyrosine phosphorylation of I-κB kinase by protein kinase C-dependent c-Src activation is involved in TNF-induced cyclooxygenase-2 expression. J Immunol. 170: 4767-4775
  10. Wei-Chien Huang, Jun-Jie Chen, and Ching-Chow Chen. (2003) c-Src dependent tyrosine phosphorylation of IKK is involved in tumor necrosis factor-induced intercellular adhesion molecule-1 expression. J Biol Chem. 14;278:9944-9952.
  11. Ching-Chow Chen, Yi-Tao Sun, Jun-Jie Chen, and Ya-Jen Chang. (2001) Tumor necrosis factor-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and I-κB kinase 1/2 in human alveolar epithelial cells. Mol Pharmacol. 59:493-500.
  12. Ching-Chow Chen, Jun-Jie Chen, and Chian-Ying Chou. (2000) Protein kinase c but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1: involvement of sequential activation of tyrosine kinase, nuclear factor-κB-inducing kinase, and I-κB kinase 2. Mol Pharmacol. 58: 1479-1489.
  13. Ching-Chow Chen, Yi-Tao Sun, Jun-Jie Chen and Kuo-Tung Chiu. (2000) TNF- α -induced cyclooxygenase-2 expression in human epithelial cells: involvement of phospholipase C, protein kinase C, tyrosine kinase, NF-κB-inducing kinase, and I-κB kinase 1/2 pathway. J. Immunol. 165:2719-2728.

會議及研討會論文：

  1. Jun-Jie Chen, Wei-Chieng Huang, Ching-Chow Chen. Transcriptional regulation of Cyclooxygenase-2 Proteasome inhibitor MG132 involves CRE element binding CCAAT/enhancer binding protein and Recruitment of CBP. (2005) Miami Nature Biotechnology winter symposia, 邁阿密，美國
  2. Jun-Jie Chen, Ching-Chow Chen. Transcriptional regulation of DR-5 in response to proteasome inhibitors involves reactive oxygen species-mediated activation of NF-kB and p53. (2007) The 22th Joint Annual Conference of Biomedical Sciences. 臺北, 臺灣. (口頭報告)
  3. Jun-Jie Chen, Chia-Wei Chou, Yu-Fan Chang and Ching-Chow Chen. Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kB and reactive oxygen species-mediated p53 activation. (2008) Annual conference of Experimental Biology. 聖地牙哥，美國.
  4. Jun-Jie Chen, J. Silvio Gutkind, and Baolin Zhang. Differential susceptibility of oral cancer cell lines to apoptosis induction via TRAIL death receptors. (2010) AACR cell death meeting. 聖地牙哥，美國.
  5. Jun-Jie Chen, Steen Knudsen, Wiktor Mazin, Jesper Dahlgaard and Baolin Zhang. A 71-gene signature of TRAIL sensitivity in cancer cells. (2011) 23rd EDRN Steering Committee Meeting., 美國
  6. Jun-Jie Chen, Zhang Baolin. Suppression of H-Ras activity enhances TRAIL-induced apoptosis through upregulation of cell surface expression of death receptor 5. (2012) AACR tumor immunology meeting, 邁阿密，美國。
  7. Chia-Yun Lin, Jun-Jie Chen. Epidermal growth factor inhibitor Erlotinib sensitized TRAIL-mediated apoptosis through regulation of c-FLIP expression in human lung cancer cells. (2015) Cold spring harbor asia (Precision cancer biology and medicine), 蘇州，中國.
  8. Wei-Shiuan Wu, Chia-Yun Lin, Jun-Jie Chen. EGFR tyrosine kinase inhibitors sensitized TRAIL-mediated cell death by regulating surface DR5 and c-FLIP expression in human hepatocellular carcinoma cells.(2016) AACR new horizons in cancer research meeting.上海，中國.
  9. Yi-Ching Shen, Wei-Shiuan Wu, Chia-Yun Lin, Jun-Jie Chen. Src kinase inhibitor dasatinib sensitized TRAIL-mediated apoptosis through regulation of c-FLIP expression in human cancer cells.(2017) Cold spring harbor asia (From Targeted to Immune Therapies) 蘇州, 中國.

學術榮譽：

  1. 2007 臺灣藥理學會年輕研究員獎
  2. 2006 第 16 屆中國化學公司王民寧基金會論文獎
  3. 2005 臺灣大學醫學院傑出論文獎

專利：

  1. CN116947999A
  2. 小分子抗菌多肽、製備方法及其用途-碳雲智肽科技股份有限公司

研究及專案計畫：

  1. 探索蛋白解體抑制劑和TRAIL協同治療腫瘤的機制:從細胞到活體 ，國科會 (103-2320-B-650-001) ，執行期間: 2014/08/01～2015/07/31。
  2. 缺氧誘導碳酸甘酶IX和藥物反應，腫瘤通路間的相關性：整合分析NCI60 平臺和臨病人表型的特徵，國科會–國際合作研究計畫(104-2923-B-650-001-MY3)，執行期間:2015/01/01～2017/12/31。共同主持人: Silvia Patorekova Ph.D. (斯洛伐克國家科學院病毒研究所主任教授)

任教科目:

  1. 藥理學
  2. 進階藥理學